Labmethods / biomarkers sp 122 comparison of atheromatous disease in high risk populations reveals a distinctasociation of risk factors among patient populations and a stricking relevance forglycemic control in diabetic nephropathy

Introduction and Aims: Patients with Chronic Kidney Disease (CKD) and/or Diabetes are at a high risk for cardiovascular (CV) disease. Improved outcomes require a better understanding of specific risk factors that distinctly modulate the incidence of atheromatous disease. Herein. we compared the distinct and combined impact of CKD and of diabetes (DM) on the development of atheromatous disease, and prevalent risk factors per condition. Methods: Cross sectional study in 2088 asymptomatic patients categorized as: 1) General Population (2 CV risk factors, no DM, estimated glomerular filtration rate (eGFR )>60 ml/min); 2) CKD,no DM; 3) DM, eGFR>60 ml/min, proteinuria<300 mg/dl; 4) Established diabetic nephropathy (DN). Carotid ultrasound of left and right carotid arteries evaluated intima-media thickness (IMT) in the common, bulb, internal and external carotid. Carotid plaque (CP) was defined as IMT>1.5mm. Multivariate Logistic Regression analysis examined the variables independently associated with the presence of CP, including glycosylated haemoglobin (HbA1c) in diabetics. Results: Table 1 shows the percent of patients with CP among the 4 populations of patients categorized by age.Table 2 shows the results of the multivariate analyses. There is a distinct association between classical risk factors and CP among the 4 subpopulation of patients. In DN, age and Triglycerydes are the only classical risk factors independently associated with CP. Also, exclusively in DN, HbA1 is independently associated with the presence of CP. Conclusions: Our findings confirm the high prevalence of atheromatous disease in asymptomatic high CV risk patients with a distinct association of risks factors among patient populations. Importantly, in diabetic nephropathy, HbA1C emerges as a main risk factor independently associated with the presence of carotid plaques. SP123 PREDICTIVE VALUE OF TRADITIONAL AND NOVEL RISK FACTORS FORCARDIOVASCULAR DISEASE AND END STAGE RENAL DISEASE IN PATIENTSWITH CHRONIC KIDNEY DISEASE