Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Heribert Schunkert,Inke R König,Sekar Kathiresan,Muredach P Reilly,Themistocles L Assimes,Hilma Holm,Michael Preuss,Alexandre F R Stewart,Maja Barbalic,Christian Gieger,Devin Absher,Zouhair Aherrahrou,Hooman Allayee,David Altshuler,Sonia S Anand,Karl Andersen,Jeffrey L Anderson,Diego Ardissino,Stephen G Ball,Anthony J Balmforth,Timothy A Barnes,Diane M Becker,Lewis C Becker,Klaus Berger,Joshua C Bis,S Matthijs Boekholdt,Eric Boerwinkle,Peter S Braund,Morris J Brown,Mary Susan Burnett,Ian Buysschaert,John F Carlquist,Li Chen,Sven Cichon,Veryan Codd,Robert W Davies,George Dedoussis,Abbas Dehghan,Serkalem Demissie,Joseph M Devaney,Patrick Diemert,Ron Do,Angela Doering,Sandra Eifert,Nour Eddine El Mokhtari,Stephen G Ellis,Roberto Elosua,James C Engert,Stephen E Epstein,Ulf de Faire,Marcus Fischer,Aaron R Folsom,Jennifer Freyer,Bruna Gigante,Domenico Girelli,Solveig Gretarsdottir,Vilmundur Gudnason,Jeffrey R Gulcher,Eran Halperin,Naomi Hammond,Stanley L Hazen,Albert Hofman,Benjamin D Horne,Thomas Illig,Carlos Iribarren,Gregory T Jones,J Wouter Jukema,Michael A Kaiser,Lee M Kaplan,John J P Kastelein, Kay-Tee Khaw,Joshua W Knowles,Genovefa Kolovou,Augustine Kong,Reijo Laaksonen,Diether Lambrechts,Karin Leander,Guillaume Lettre,Mingyao Li,Wolfgang Lieb,Christina Loley,Andrew J Lotery,Pier M Mannucci,Seraya Maouche,Nicola Martinelli,Pascal P McKeown,Christa Meisinger,Thomas Meitinger,Olle Melander,Pier Angelica Merlini,Vincent Mooser,Thomas Morgan,Thomas W Mühleisen,Joseph B Muhlestein,Thomas Münzel,Kiran Musunuru,Janja Nahrstaedt,Christopher P Nelson,Markus M Nöthen,Oliviero Olivieri,Riyaz S Patel,Chris C Patterson,Annette Peters,Flora Peyvandi,Liming Qu,Arshed A Quyyumi,Daniel J Rader,Loukianos S Rallidis,Catherine Rice,Frits R Rosendaal,Diana Rubin,Veikko Salomaa,M Lourdes Sampietro,Manj S Sandhu,Eric Schadt,Arne Schäfer,Arne Schillert,Stefan Schreiber,Jürgen Schrezenmeir,Stephen M Schwartz,David S Siscovick,Mohan Sivananthan,Suthesh Sivapalaratnam,Albert Smith, Tamara B Smith,Jaapjan D Snoep,Nicole Soranzo,John A Spertus,Klaus Stark, Kathy Stirrups,Monika Stoll,W H Wilson Tang,Stephanie Tennstedt,Gudmundur Thorgeirsson,Gudmar Thorleifsson,Maciej Tomaszewski,Andre G Uitterlinden,Andre M van Rij,Benjamin F Voight,Nick J Wareham,George A Wells,H-Erich Wichmann,Philipp S Wild,Christina Willenborg,Jaqueline C M Witteman,Benjamin J Wright,Shu Ye,Tanja Zeller,Andreas Ziegler,Francois Cambien,Alison H Goodall,L Adrienne Cupples,Thomas Quertermous,Winfried März,Christian Hengstenberg,Stefan Blankenberg,Willem H Ouwehand,Alistair S Hall,Panos Deloukas,John R Thompson,Kari Stefansson,Robert Roberts,Unnur Thorsteinsdottir,Christopher J O'Donnell,Ruth McPherson,Jeanette Erdmann,Nilesh J Samani

NATURE GENETICS（2011）

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摘要

Heribert Schunkert and colleagues report a meta-analysis of 14 genome-wide association studies of coronary disease (CAD) followed by replication in additional cohorts. They confirm 10 previously associated loci and identify 13 loci newly associated with CAD.

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bioinformatics,biomedical research

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