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The cytoskeleton forms a dynamic framework inside cells, supporting their shape and their movement. My lab focusses on the cytoskeleton of endothelial cells, the cell that line blood vessels. In healthy blood vessels, the endothelial cells control the passage of oxygen and nutrients from the blood to the tissue below, and return waste products in the opposite direction. Their cytoskeleton regulates this barrier function, and also controls the shape of the cells to allow blood to flow smoothly over the surface. Dysregulation of the cytoskeleton leads to disruption of the normal barrier and pathological flow.
When tissues become deprived of oxygen, as in heart disease or stroke, the body can activate endothelial cells in existing blood vessels, causing them to grow out towards the diseased area and form new blood vessels. This process is called angiogenesis. These new blood vessels improve perfusion of the damaged tissue and promote healing and recovery.
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JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGYno. 6 (2022): 1120-1136
Sarah Line Bring Truelsen,Nabi Mousavi,Haoche Wei, Lucy Harvey,Rikke Stausholm, Erik Spillum,Grith Hagel,Klaus Qvortrup,Ole Thastrup,Henrik Harling,Harry Mellor,Jacob Thastrup
medrxiv(2020)
medRxiv (Cold Spring Harbor Laboratory) (2020)
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Ashton Faulkner, Anita Tamiato,William Cathery,Andrea Rampin,Carlo Maria Caravaggi,Eva Jover, Steve Allen,Harry Mellor,David Hauton,Lisa C. Heather,Gaia Spinetti,Paolo Madeddu
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