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Inflammation and oxidative stress contribute to numerous pathologies including cancer and decreased reproductive health. Our studies examine the mechanisms through which immune-endocrine interactions contribute to hormonal carcinogenesis and control steroid hormone biosynthesis, metabolism and action.
Ovarian cancer is the leading cause of death from gynecological malignancies due to the late stage at which it is usual detected. With the exception of the laying hen no other animals are inflicted with spontaneous ovarian surface epithelial cancer that replicates the human disease. Using the chicken as a model for ovarian cancer our studies examine the role of inflammation and oxidative stress in etiology of ovarian cancer. Our studies involve dietary intervention strategies and examine basic mechanisms of cancer pathogenesis.
Ovarian cancer is the leading cause of death from gynecological malignancies due to the late stage at which it is usual detected. With the exception of the laying hen no other animals are inflicted with spontaneous ovarian surface epithelial cancer that replicates the human disease. Using the chicken as a model for ovarian cancer our studies examine the role of inflammation and oxidative stress in etiology of ovarian cancer. Our studies involve dietary intervention strategies and examine basic mechanisms of cancer pathogenesis.
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Pui-Wah Choi, Wai Wing So,Junzheng Yang,Shubai Liu, Ka Kui Tong,Kin Ming Kwan,Jamie S.-L. Kwok,Stephen K. W. Tsui,Shu-Kay Ng,Karen H. Hales,Dale B. Hales,William R. Welch,
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