0864 Sleep Prior to Cardiac Arrest Is Associated with Physical Health-Related Quality of Life Early in Recovery

Abstract Introduction Poor sleep increases risk of sudden cardiac arrest (CA). Survivors of hospital stays experience lasting sleep issues, and poor post-hospitalization sleep is associated with lower health-related quality of life (HRQoL) during recovery. It is unknown, however, whether better pre-CA sleep may serve as a premorbid asset that may prospectively predict HRQoL during early recovery beyond post-CA sleep. Methods In this interim analysis of an observational cohort study, 129 CA survivors were recruited from a large urban hospital. Upon discharge, patients reported on sleep in the month before their CA using the Pittsburgh Sleep Quality Index (PSQI). Post-CA physical function regarding activities of daily living was assessed via the Physical Self-Maintenance Scale. Demographic and CA severity variables were collected from medical records. A month later, patients reported on their HRQoL using the 36-item Short Form (SF-36) and post-CA sleep with the PSQI. We hypothesized that worse premorbid sleep quality (global PSQI score) would be associated with worse physical and mental HRQoL component scores (SF-36 PCS and MCS) at 1 month. Results Worse premorbid sleep (M = 8.67, SD = 4.03) was associated with worse PCS 1-month post- discharge (B = -0.68, p < .01), after adjusting for sex at birth, age, ethnicity, and time from CA to return of spontaneous circulation, an index of CA severity. Premorbid sleep was still a significant predictor (B = -0.58, p =.02) after adjusting for patients’ physical function at discharge and sleep one month later (M = 7.67, SD = 4.62). However, worse premorbid sleep was not significantly associated with worse MCS after adjusting for the same covariates (B = -0.50, p = .07). This remained non-significant controlling for physical function at discharge and sleep quality after a month (B = -0.22, p = .49). Conclusion These results suggest that people’s sleep before suffering a CA may predict their post-CA physical HRQoL, in ways that are at least partially independent from CA severity, physical function at discharge, and post-CA sleep. Future research should identify mechanisms (e.g., inflammation) by which a reserve of quality sleep improves post-CA physical recovery. Support (if any) This research was supported by NHLBI grants R01-HL151850 and R01-HL153311.