Computational fluid dynamics method for determining the rotational diffusion coefficient of cells

This work presents a straightforward computational method to estimate the rotational diffusion coefficient (D-r) of cells and particles of various sizes using the continuum fluid mechanics theory. We calculate the torque (Gamma) for cells and particles immersed in fluids to find the mobility coefficient mu and then obtain the D-r by substituting Gamma in the Einstein relation. Geometries are constructed using triangular mesh, and the model is solved with computational fluid dynamics techniques. This method is less intensive and more efficient than the widely used models. We simulate eight different particle geometries and compare the results with previous literature. (C) 2024 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).