Severe, persistent, disruptive fatigue higher in young women among community-based post SARS-CoV-2 study
Archives of Physical Medicine and Rehabilitation(2024)
摘要
Research Objectives
To describe the most likely persistent symptoms of PASC, their natural history, and the profile of those likely affected.
Design
Prospective, longitudinal design (baseline, 6 month, and annual follow-up visits), with 2 arms: virtual and in-person.
Setting
A large, metropolitan community health system in the Northeastern U.S.
Participants
323 participants treated for SARS-CoV-2.
Interventions
Observational study.
Main Outcome Measures
SARS-CoV-2 history and treatment, PASC symptom reporting, socio-demographic variables, past medical history (PMH), patient-reported outcome measures (PROs; including FACIT-F fatigue, ESAS, EQ5D), cognitive tests (Color-Word Interference Test, Arithmetic, Matrix Reasoning), health behavior reporting. In-person subjects also had physical exams, grip strength, bioimpedance, 2-minute walk distance (2MWD), and blood draw.
Results
323 participants completed baseline symptom reporting, of whom 61 participants indicated they had clinically significant fatigue (23.1% of overall cohort reporting baseline symptoms). 141 subjects also completed in-depth baseline questionnaires, including the FACIT-F fatigue, with 37 scoring in the severe fatigue range. This group- the entire severe fatigue cohort- was statistically significantly younger, female, had more anxiety and depression, had a higher resting heart rate, reported more sick days, and were less physically active post-COVID. The severely fatigued reported that their overall health, diet, weight, and uninterrupted sleep were worse than those not severely fatigued post-COVID (p=0.02-0.0002). The significantly fatigued group also had lower wellbeing scores, more depressive symptoms, and a greater number of all symptoms. Fatigue was statistically significantly correlated with all PROs administered but did not correlate with cognitive performance.
Conclusions
Fatigue is a common symptom associated with lower PRO scores of wellbeing and function. Those severely fatigued were younger, female, and have a past medical history of anxiety, depression, chronic kidney disease and physical inactivity.
Author(s) Disclosures
ZM Younossi- consulting fees: Bristol Myers Squibb, Gilead, Intercept, Novo Nordisk, Novartis, Terns, Merck, Quest, Siemens and Madrigal. All other authors: Nothing to disclose.
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关键词
COVID,Fatigue,Health Behaviors,Women
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