Passive assessment of tapping speed through smartphone is useful for monitoring multiple sclerosis

Introduction: Continuously acquired smartphone keyboard interactions may be useful to monitor progression in multiple sclerosis (MS). We aimed to study the correlation between tapping speed (TS), measured as keys/second, and baseline disability scales in patients with MS.Methods: Single-center prospective study in patients with MS. We passively assessed TS during first week, measured by an “in house” smartphone application. Reliability was assessed by intraclass correlation coefficient (ICC). Correlations between median and maximum keys/second of first week of assessment and baseline disability measures were explored.Results: One-hundred three patients were included: 62.1% women, with a median (IQR) age of 47 (40.4-54.8) years-old and an EDSS score of 3.0 (2.0-4.0). Distribution by MS subtypes was: 77.7% relapsing-remitting MS (RRMS), 17.5% secondary-progressive MS (SPMS) and 4.9% primary-progressive MS (PPMS).ICC during first week was 0.714 (p<0.00001). Both median and maximum keys/second showed a negative correlation with Expanded Disability Status Score, 9-hole peg test and timed 25-foot walk and a positive correlation with Processing Speed Test CogEval® raw and Z-score. Median and maximum keys/second were lower in patients diagnosed with SPMS than in RRMS. Both measures of tapping speed were associated with MS phenotype independently of age.Conclusion: TS measured through our application is reliable and correlates with baseline disability scales.