Association Between Head Computed Tomography Findings and In-Hospital Mortality in COVID-19 Patients

Objective: The present study investigated the association between head computed tomography (CT) findings and mortality in patients with COVID-19. Specifically, we focused on low -density lesions identified on head CT screenings. Materials and methods: We performed a single -center, retrospective cohort study based on data obtained from the medical charts of inpatients admitted to the Tokyo Metropolitan Hiroo Hospital between January 1 and December 31, 2021. We focused on the basal ganglia --a representative anatomical region for assessing routine head CT in patients with COVID-19. Patients were divided into two groups based on the presence or absence of low -density lesions in the basal ganglia. The primary outcome was all -cause in -hospital mortality, and the secondary outcome was the length of hospital stay. We performed multivariable regression analyses for outcomes to adjust for patients' background and disease severity. Results: During the study period, 1,906 COVID-19 patients were admitted to our facility. Among them, 1,203 patients underwent head CT evaluations and were included in this study. The median age was 56 years (interquartile range: 43-76 years) and 725 patients (60.3%) were male. A total of 235 (19.5%) patients required oxygen therapy on admission and 1,051 (87.4%) patients had pneumonia. Crude in -hospital mortality was 6.1% and the median length of hospital stay was 10 days (interquartile range: 8-14 days). The multivariate regression analyses showed that low -density lesions in the basal ganglia were significantly associated with increased in -hospital mortality and prolonged hospital stay. Conclusions: The presence of ischemic changes in the basal ganglia denoted by low -density findings may be a promising prognostic factor in patients with COVID-19.