Platinum Nanoparticles Regulated V₂C MXene Nanoplatforms with NIR‐II Enhanced Nanozyme Effect for Photothermal and Chemodynamic Anti‐infective Therapy

AbstractGiven the challenge of multidrug resistance in antibiotics, non‐antibiotic‐dependent antibacterial strategies show promise for anti‐infective therapy. V2C MXene‐based nanomaterials have demonstrated strong biocompatibility and photothermal conversion efficiency (PCE) for photothermal therapy (PTT). However, the limitation of V2C MXene's laser irradiation to the near‐infrared region I (NIR‐I) restricts tissue penetration, making it difficult to achieve complete bacterial eradication with single‐effect therapeutic strategies. To address this, Pt nanoparticles (Pt NPs) were attached to V2C, forming artificial nanoplatforms (Pt@V2C). Pt@V2C exhibited enhanced PCE (59.6%) and a longer irradiation laser (NIR‐II) due to the surface plasmon resonance effect of Pt NPs and V2C. Notably, Pt@V2C displayed dual enzyme‐like activity with chemodynamic therapy (CDT) and NIR‐II enhanced dual enzyme‐like activity. The biocatalytic mechanism of Pt@V2C was elucidated using density functional theory. In an in vivo animal model, Pt@V2C effectively eliminated methicillin‐resistant Staphylococcus aureus from deep‐seated tissues in subcutaneous abscesses and bacterial keratitis environments, accelerating abscess resolution and promoting wound and cornea healing through the synergistic effects of PTT/CDT. Transcriptomic analysis revealed that Pt@V2C targeted inflammatory pathways, providing insight into its therapeutic mechanism. This study presents a promising therapeutic approach involving hyperthermia‐amplified biocatalysis with Pt NPs and MXene nanocomposites.This article is protected by copyright. All rights reserved