Correlation Between Impaired Sensitivity to Thyroid Hormones and Serum Uric Acid in Female Patients with Obesity and After Laparoscopic Sleeve Gastrectomy

Objective An alterable risk factor for hyperuricemia is obesity. Additionally, obese persons may have a moderate form of acquired resistance to thyroid hormones. Thyrotropin (TSH), thyroid hormones, and obesity all interact subtly. However, the connection between thyroid hormone sensitivity and hyperuricaemia in obese patients both before and after laparoscopic sleeve gastrectomy (LSG) has not yet been clarified. The objective of our study was to investigate the connection between impaired thyroid hormone sensitivity and elevated uric acid (UA) levels before and after LSG. Methods In total, 1,054 euthyroid patients with obesity (481 males, 573 females), 248 (143 females) of whom underwent subsequent LSG, were enrolled in this retrospective study. Anthropometric measurements and thyroid hormone and UA levels were taken before and 3 months after LSG. Results Female patients with obesity with impaired sensitivity to thyroid hormones had higher UA levels (P for trend < 0.01). The odds ratio of the fourth versus first quartile of TFQI, TSHI, and TT4RI were 4.285 [confidence interval (CI): 1.360–13.507], 3.700 [CI: 1.276–10.729], and 2.839 [CI: 1.014–7.948], respectively, with robust relationships with female hyperuricemia (all P < 0.05). However, there was only a positive correlation between the decline in UA levels and TFQI, TSHI, and TT4RI in females following LSG. Conclusion Female hyperuricemia is correlated with higher thyroid hormone resistance index scores. Resistance to thyroid hormones was greatly improved by LSG. The decrease in UA levels after surgery is correlated with the improvement of thyroid hormone resistance after LSG.