Dissolution thermodynamics and solubility prediction of satranidazole in mono-solvent systems at various temperatures using a single determination

The reported mole fraction solubility data of satranidazole (SAT) in 18 mono-solvents at five different temperatures (T = 293.2K to 313.2 K) and atmospheric pressure (p = 0.1MPa) collected from the literature were revisited from another physicochemical point of view. The solubility of SAT in 12 mono-solvents was correlated by a newly developed model and six mono-solvents were excluded from correlation due to the non-availability of solvent parameters. Additionally, apparent thermodynamic quantities of dissolution and mixing were calculated based on the van't Hoff and Gibbs equations by using mole fraction solubilities and reported enthalpy and temperature of fusion of SAT. Results were interpreted in terms of possible intermolecular interactions.