Concurrent factors associated with adherence to adjuvant endocrine therapy among women with non-metastatic breast cancer
Journal of Cancer Survivorship(2024)
摘要
Adjuvant endocrine therapy (AET) reduces breast cancer morbidity and mortality, yet women often report suboptimal adherence. Though correlates of AET adherence are well-documented, few studies examine the relative importance of multi-level factors associated with adherence. The aim of this study was to identify factors most strongly associated with AET adherence in women with breast cancer. Between 10/2019 and 6/2021, women (N = 100) with non-metastatic, hormone receptor-positive breast cancer, taking AET who reported AET-related distress enrolled into a clinical trial. Participants completed baseline measures, including the Medication Adherence Rating Scale-5, sociodemographics, and validated measures of anxiety, depression, medication-taking self-efficacy, social support, and treatment satisfaction. We created a latent factor and tested associations between sociodemographic, medical, and psychosocial characteristics and adherence. Associated predictors (p < .10) were entered into a structural model, which was corroborated via multivariate regression modeling. A four-indicator latent adherence factor demonstrated good model fit. Participants (Mage = 56.1 years, 91
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关键词
Adjuvant endocrine therapy,Adherence,Breast cancer,Medication-taking self-efficacy,Structural equation modeling
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