The Role of NAD⁺ and NAD⁺-Boosting Therapies in Inflammatory Response by IL-13

The essential role of nicotinamide adenine dinucleotide(+)(NAD(+)) in redox reactions during oxidative respiration is well known, yet the coenzyme and regulator functions of NAD(+)in diverse and important processes are still being discovered. Maintaining NAD(+)levels through diet is essential for health. In fact, the United States requires supplementation of the NAD(+)precursor niacin into the food chain for these reasons. A large body of research also indicates that elevating NAD(+)levels isbeneficial for numerous conditions, including cancer, cardiovascular health, inflammatory response, and longevity. Consequently, strategies have been created to elevate NAD(+)levels through dietary supplementation with NAD(+)precursor compounds. This paper explores current research regarding these therapeutic compounds. It then focuses on the NAD(+)regulation of IL-13 signaling, which is a research area garnering little attention. IL-13 is a critical regulator of allergic response and is associated with Parkinson's disease and cancer. Evidence supporting the notion that increasing NAD(+)levels might reduce IL-13 signal-induced inflammatory response is presented. The assessmentis concluded with an examination of reports involving popular precursor compounds that boostNAD+and their associations with IL-13 signaling in the context of offering a means for safely andeffectively reducing inflammatory response by IL-13.