The Impact of Nanomedicine on Soft Tissue Sarcoma Treated by Radiotherapy and/or Hyperthermia: A Review

Simple Summary Our manuscript addresses a noteworthy gap in the cancer research literature through an in-depth exploration of existing studies on the potential application of nanoparticles in radiotherapy and/or hyperthermia treatment for soft tissue sarcomas (STS). While nanoparticles have shown promising results in various cancer types, STS, known for its radioresistant and aggressive nature, lacks comprehensive research. Our aim is to analyze and compare the current body of literature, in order to provide a new perspective on the use of nanoparticles in enhancing radiotherapy and hyperthermia treatment outcomes for STS. The significance of our work lies in its potential to consolidate knowledge, identify research gaps, and offer insights into nanoparticle-based therapies for STS. By shedding light on existing studies, our literature review provides valuable information for the research community, fostering a deeper understanding of potential strategies for improving therapeutic approaches to this challenging form of cancer.Abstract This article presents a comprehensive review of nanoparticle-assisted treatment approaches for soft tissue sarcoma (STS). STS, a heterogeneous group of mesenchymal-origin tumors with aggressive behavior and low overall survival rates, necessitates the exploration of innovative therapeutic interventions. In contrast to conventional treatments like surgery, radiotherapy (RT), hyperthermia (HT), and chemotherapy, nanomedicine offers promising advancements in STS management. This review focuses on recent research in nanoparticle applications, including their role in enhancing RT and HT efficacy through improved drug delivery systems, novel radiosensitizers, and imaging agents. Reviewing the current state of nanoparticle-assisted therapies, this paper sheds light on their potential to revolutionize soft tissue sarcoma treatment and improve patient therapy outcomes.