Copper-catalyzed desymmetric silylative-cyclization of 1,6-diynes for synthesis of spirocyclic compounds
ORGANIC CHEMISTRY FRONTIERS(2024)
摘要
Spiro rings such as spirooxindoles and spiroindanones are core skeletons in many pharmaceutically active molecules and natural products. Herein, we developed a copper-catalyzed cascade silylation-cyclization reaction of 1,6-diynes which enabled the rapid construction of silyl-functionalized spirocyclic compounds. A variety of racemic and optically pure spirocyclic oxindole, indanone, quinolinone, and tetralone derivatives were obtained in high yields with excellent enantioselectivities and high stereoselectivities. The silylative-cyclization desymmetrization of 1,6-diynes has been realized. This reaction enabled the construction of silyl-functionalized spirocyclic oxindoles, indanone, quinolinone, and tetralone derivatives from readily available 1,6-diynes.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要