Semi-supervised low-dose SPECT restoration using sinogram inner-structure aware graph neural network

Objective. To mitigate the potential radiation risk, low-dose single photon emission computed tomography (SPECT) is of increasing interest. Numerous deep learning-based methods have been developed to perform low-dose imaging while maintaining image quality. However, most existing methods seldom explore the unique inner-structure inherent within sinograms. In addition, traditional supervised learning methods require large-scale labeled data, where the normal-dose data serves as annotation and is intractable to acquire in low-dose imaging. In this study, we aim to develop a novel sinogram inner-structure-aware semi-supervised framework for the task of low-dose SPECT sinogram restoration. Approach. The proposed framework retains the strengths of UNet, meanwhile introducing a sinogram-structure-based non-local neighbors graph neural network (SSN-GNN) module and a window-based K-nearest neighbors GNN (W-KNN-GNN) module to effectively exploit the inherent inner-structure within SPECT sinograms. Moreover, the proposed framework employs the mean teacher semi-supervised learning approach to leverage the information available in abundant unlabeled low-dose sinograms. Main results. The datasets exploited in this study were acquired from the (Extended Cardiac-Torso) XCAT anthropomorphic digital phantoms, which provide realistic images for imaging research of various modalities. Quantitative as well as qualitative results demonstrate that the proposed framework achieves superior performance compared to several state-of-the-art reconstruction methods. To further validate the effectiveness of the proposed framework, ablation and robustness experiments were also performed. The experimental results show that each component of the proposed framework effectively improves the model performance, and the framework exhibits superior robustness with respect to various noise levels. Besides, the proposed semi-supervised paradigm showcases the efficacy of incorporating supplementary unlabeled low-dose sinograms. Significance. The proposed framework improves the quality of low-dose SPECT reconstructed images by utilizing sinogram inner-structure and incorporating supplementary unlabeled data, which provides an important tool for dose reduction without sacrificing the image quality.