A multi-domain model for microcirculation in optic nerve: blood flow and oxygen transport
arxiv(2024)
摘要
Microcirculation of blood and oxygen transport play important roles in
biological function of optic nerve and are directly affected by damages or
pathologies. This work develops a multi-domain model for optic nerve, that
includes important biological structures and various physical mechanisms in
blood flow and oxygen delivery. The two sets of vasculature network are treated
as five domains in the same geometric region, with various exchanges among them
(such as Darcy's law for fluid flow) and with the tissue domain (such as water
leak, diffusion). The numerical results of the coupled model for a uniform case
of vasculature distribution show mechanisms and scales consistent with
literature and intuition. The effects of various important model parameters
(relevant to pathological conditions) are investigated to provide insights into
the possible implications. The vasculature distribution (resting volume
fractions here) has significant impacts on the blood circulation and could lead
to insufficient blood supply in certain local region and in turn affect the
oxygen delivery. The water leak across the capillary wall will have nontrivial
effects after the leak coefficients pass a threshold. The periodic arterial
pressure conditions lead to expected periodic patterns and stable spatial
profiles, and the uniform case is almost the averaged version of periodic case.
The effects of viscosity, the stiffness of blood vessel wall, oxygen demand,
etc. have also been analyzed. The framework can be extended to include ionic
transport or to study the retina when more biological structural information is
available.
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