The Effect of Eight Weeks of Circuit Resistance Training on Serum Levels of GPR119 and -Arrestin1 in Individuals with Type 2 Diabetes

Background. The rising prevalence of diabetes has elevated its status as a significant health concern. Diabetes is a metabolic disorder characterized by elevated blood glucose levels, leading to various pathological changes such as neuropathy, nephropathy, retinopathy, gastrointestinal disorders, immune system impairment, vascular damage, and impaired tissue regeneration. Objectives. This study aimed to examine the effects of eight weeks of circuit resistance training (CRT) on serum levels of GPR119 and beta-Arrestin1 in individuals with type 2 diabetes. Methods. Twenty male persons with type 2 diabetes (T2DM), who visited the diabetes clinic in Towhid Hospital and the Diabetes Association of Sanandaj city, were randomly divided into two groups: a control group (n=10) and an experimental group (n=10). CRT was conducted for eight weeks (three non-consecutive sessions per week). The exercise program consisted of gradually increasing sets, intensity, and volume, starting from 2 sets at 40% of 1RM (15 repetitions) in the initial sessions, and progressing to 4 sets at 80% of 1RM (6 repetitions) in the final sessions. Rest intervals of 20 to 30 seconds between sets and 3 minutes between rounds were implemented. GPR119 and beta-Arrestin1 levels were assessed via ELISA method. Results. Repeated measures analysis of variance revealed that CRT significantly increased GPR119 and beta-Arrestin1 levels in the experimental group (p=0.023 and p=0.032, respectively). Conclusion. Based on the reduction of insulin resistance (IR) in the persons with persons with T2DM in adaptation with CRT, and the roles of GPR119 and beta-Arrestin1 in IR, the therapeutic implications of CRT via these proteins may be expected.