Survival of patients living with HIV and cancer in Cali, Colombia

Luis Gabriel Parra-Lara, Juan Pablo Arango-Ibanez, Juan J. Martinez-Arboleda,Juan C. Bravo,Angela R. Zambrano,Paola Collazos,Francisco Andino, Angelica Badillo, Sebastian Estrada,Fernando Rosso

COLOMBIA MEDICA(2023)

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摘要
Background:People living with HIV have an increased risk of cancer compared to the general population. However, with the increase in life expectancy and advances in antiretroviral therapy, the survival of patients with cancer and HIV has changed. Objective:To determine the survival of patients living with HIV and cancer in Cali, Colombia. Methods:A retrospective cohort study was conducted at the Fundacion Valle del Lili, Cali, Colombia. Data from the HIV database was crossed with data from the hospital and population-based cancer registries between 2011-2019. Patients <18 years, limited available clinical information on the diagnosis and treatment of HIV and cancer, and non-oncological tumor diagnosis were excluded. Results:A total of 173 patients were included. The frequencies of AIDS-defining neoplasms were: Non-Hodgkin lymphoma (42.8%), Kaposi sarcoma (27.8%), and cervical cancer (4.6%). Overall survival was 76.4% (95% CI 68.9-82.3) at five years. Poorer survival was found in patients with AIDS-defining infections (56.9% vs. 77.8%, p=0.027) and non-AIDS-defining infections (57.8% vs. 84.2%, p=0.013), while there was better survival in patients who received antiretroviral therapy (65.9% vs. 17.9%, p=0.021) and oncological treatment (66.7% vs. 35.4%, p<0.001). The presence of non-AIDS-defining infections increases the risk of dying (HR = 2.39, 95% CI 1.05-5.46, p=0.038), while oncological treatment decreases it (HR = 0.33, 95% CI 0.14-0.80, p=0.014). Conclusions:In people living with HIV, Non-Hodgkin lymphoma and Kaposi sarcoma are the most common neoplasms. Factors such as AIDS-associated and non-AIDS-associated infections have been identified as determinants of survival. Cancer treatment seems to improve survival.
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关键词
Antiretroviral Therapy,Acquired Immuno-deficiency Syndrome,Sarcoma Kaposi,Uterine Cervical Neoplasms,Lymphoma Non-Hodgkin,HIV Infections,Oncogenic Viruses,Coinfection,Carcinoma Squa-mous Cell,Tuberculosis
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