Super-Resolution Reconstruction of Multi-Slice T2-W FLAIR MRI Improves Multiple Sclerosis Lesion Segmentation.

Due to acquisition time constraints, T2-w FLAIR MRI of Multiple Sclerosis (MS) patients is often acquired with multi-slice 2D protocols with a low through-plane resolution rather than with high-resolution 3D protocols. Automated lesion segmentation on such low-resolution (LR) images, however, performs poorly and leads to inaccurate lesion volume estimates. Super-resolution reconstruction (SRR) methods can then be used to obtain a high-resolution (HR) image from multiple LR images to serve as input for lesion segmentation. In this work, we evaluate the effect on MS lesion segmentation of three SRR approaches: one based on interpolation, a state-of-the-art self-supervised CNN-based strategy, and a recently proposed model-based SRR method. These SRR strategies were applied to LR acquisitions simulated from 3D T2-w FLAIR MRI of MS patients. Each SRR method was evaluated in terms of image reconstruction quality and subsequent lesion segmentation performance. When compared to segmentation on LR images, the three considered SRR strategies demonstrate improved lesion segmentation. Furthermore, in some scenarios, SRR achieves a similar segmentation performance compared to segmentation of HR images.Clinical relevance- This study demonstrates the positive impact of super-resolution reconstruction from T2-w FLAIR multi-slice MRI acquisitions on segmentation performance of MS lesions.