Vitamin D deficiency and bone density in children with celiac disease in southern Iran: An academic tertiary referral center's experience

Naser Honar, Mohsen Davoodi, Michel Azizi,Forough Saki

Research Square (Research Square)(2023)

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摘要
Abstract Objectives Celiac disease is not limited to the digestive tract. Patients are at high risk for secondary osteoporosis, rendering the monitoring of bone density critical. We aimed to examine vitamin D deficiency and bone density in children with celiac disease. Methods This prospective cross-sectional study was conducted in 2018–2019 in the Fars province of Iran. The study population included children with celiac disease referred to Imam Reza Clinic or Namazi Hospital within the study period. Patients were examined for vitamin D deficiency and bone density levels. Results The present study included 10 (43.5%) boys and 13 girls (56.5%) with celiac disease. Only two patients were under vitamin D supplementation (8.7%). Growth disorders were the most common reason for referral (78%). Celiac disease in most children was associated with vitamin D, calcium, and parathyroid hormone enzyme activity disorders. Increasing age was associated with vitamin D deficiency. The lumbar and femoral bone density were associated with the puberty stage but not the age or gender. Conclusions Considering that the prevalence of osteoporosis and osteopenia is very high in celiac disease patients, a proper screening program should be devised to reduce the injuries caused by undiagnosed bone disorders.
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关键词
celiac disease,bone density
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