Electrochemistry Study of Few Ru(II) and Zn(II)-Thione and Selone Complexes

Hydrogen peroxide, as a byproduct of cellular respiration through incomplete reduction of oxygen yields deleterious free radicals through the Fenton reaction with iron (II/III) and Cu(I/II). Metals, such as ruthenium and zinc, are also capable of like- Fenton reaction and the production of the hydroxide radical responsible for oxidative DNA damage. This damage manifests itself through single-strand breaks in the DNA backbone corresponding to mutation and apoptosis of cells. Thus, recent research has focused on preventing this reaction through organometallic antioxidative methods. Sulfur and selenium antioxidant compounds like dmit, dmise, and methimazole coordinate to iron and other Fenton-like metal centers. Based on the electrochemistry study, the result of cyclic voltammetry can predict whether or not these metals compounds generate hydroxyl radicals when they meet hydrogen peroxide in body by fi guring out their redox potentials. In this study, the electrochemical eff ects of these thione/selone ligands are determined through cyclic voltammetry with diff ering metal centers. Zinc complex redox activity was found to vary negligibly in changing solvent as well as scan speeds. In addition, ruthenium complexes from solvato complex precursors, their electrochemical peaks analyzed to prepare for reaction with hydrogen peroxide.