Aqueous Extract of Allium victorialis var. Platyphyllum Rhizome Improves SkinBarrier and Suppresses Inflammation

Background: Atopic dermatitis is a chronic inflammatory skin disease caused by skin barrier dysfunction. Allium victorialis var. platyphyllum (AVP) is a perennial plant considered as a vegetable and herbal medicine. This study aimed to investigate the effects of AVP on skin barrier and inflammatory response and indicate its potential as a new cosmetic materialsBRMethods and Results: High peformance liquid chromatography-ultraviolet analysis showed that AVP contains 0.12 ± 0.02 and 0.10 ± 0.01 ㎎/g of chlorogenic and gallic acids, respectively. AVP at 100 ㎍/㎖ was shown to increase the mRNA levels of filaggrin and involucrin, which are related to skin barrier function, by 1.50-fold and 1.43-fold, respectively. Based on a scratch assay, AVP at concentrations of 100 ㎍/㎖ and 200 ㎍/㎖ significantly increased wound closure rate and narrowed scratch area. AVP suppressed inflammation-related factors, such as cyclooxygenase 2 and nitric oxide, that were increased by lipopolysaccharide treatment. Additionally, AVP decreased the release of β-hexosaminidase which was increased by dinitrophenyl-bovine serum albumin treatment on RBL-2H3 cells.BRConclusions: Therefore, AVP can be developed as a functional cosmetic material for atopy management given its skin barrier protective, anti-inflammatory, and anti-pruritic effects.