Cervical cancer patient with deep venous thrombosis developing fatal ischemic stroke within 24 hours after surgery：a case report

Abstract Background: Deep venous thrombosis (DVT) including limber and pulmonary embolism is a common complication of cancer. DVT and ischemic stroke may independently or jointly lead to poor prognosis in cancer patients. Case presentation: A 36-year-old female patient, received insertion of inferior vena cava filter and oral rivaroxaban for deep venous thrombosis in limbers and pulmonary artery, was suspected of cervical cancer for a three-month history of vaginal discharge and was transferred to our hospital for further treatment. After cervical tissue biopsy and pelvic cavity magnetic resonance imaging (MRI) examination, she was diagnosed with cervical adenocarcinoma (stage Ⅱ A). She discontinued taking oral rivaroxaban two days before surgery. Within 24 hours after ovariohysterectomy, she suffered from ischemic stroke following by pulmonary embolism，and was transferred to the intensive care unit（ICU）and received therapies including mechanical ventilation, mannitol and nadroparin calcium. Nevertheless, she worsened for cerebral hernia. Eventually, her family refused further treatment for her. Conclusions: It was still a challenge for clinicians to prevent arterial and venous thrombosis in cancer patients, especially in perioperative period with elevated risk for ischemic vascular events.