THU288 An Analysis Of The Association Between Age, HbA1c, Central Corneal Thickness, And Lens Thickness Using Swept-source Optical Coherence Tomography

Abstract Disclosure: R.K. Borkhetaria: None. E.V. Karakoleva: None. N. Devireddy: None. D.B. Rosen: None. S.M. Pantanelli: None. An increase in age is positively correlated with an increase in the thickness of the crystalline lens of the eye. Lens thickness changes have also been observed in diabetics. However, whether a predictable relationship exists between HbA1c and certain biometric variables is unknown. The aim of this study was to investigate any associations between age, HbA1c levels, central corneal thickness (CCT), and lens thickness (LT) using a swept-source optical coherence tomography (SS-OCT) based optical biometer in the eyes of patients with diabetes mellitus. A retrospective, consecutive case series was conducted. CCT and LT were measured with the IOLMaster 700 swept-source optical biometer (Carl Zeiss Meditec). HbA1c of diabetics recorded within 3 months of biometry measurements were abstracted from the medical record. The data were analyzed using a linear regression model. We evaluated 391 eyes of 391 patients: 107 diabetics and 284 age-matched non-diabetics. Amongst non-diabetics, age was positively associated with LT (p<0.001), with an increase in LT of 0.02 mm per year of age. There was no association elucidated between age and CCT in this group (p=0.754). Amongst diabetics, HbA1c was independently associated with LT (p=0.005) after controlling for age, with a decrease in LT of 0.07 mm per 1-unit increase in HbA1c. Age (p=0.119) nor HbA1c (p=0.310) were associated with CCT amongst diabetics. There was a positive correlation between age and lens thickness amongst diabetics and non-diabetics. HbA1c was independently associated with lens thickness amongst diabetics. There was no correlation between age, HbA1c, and central corneal thickness. Presentation: Thursday, June 15, 2023