43426 Cutaneous T-cell Lymphoma and Dermatological Comorbidities: A National Cross-Sectional Study

Cutaneous T-cell lymphoma (CTCL) is the group of malignancies that result from the monoclonal proliferation of T-cells involving the skin. These diseases typically present with erythematous plaques or patches that can progress to painful and pruritic widespread cutaneous involvement or nodular tumor growth. Several studies have associated hemato-oncological, infectious, cardiovascular, respiratory, and gastrointestinal comorbidities with CTCL [1-3], but investigation regarding dermatological diseases associated with CTCL patients is lacking. The 2016 – 2019 National Inpatient Sample, a de-identified patient database accounting for 20% of all U.S. hospitalizations, was analyzed for adult patients with and without CTCL (including mycosis fungoides). Using a multivariable logistic regression adjusting for demographic variables, associations of CTCL with 23 dermatological diseases were determined against the general inpatient population. In this study, 12,675 CTCL patients were identified out of 121,074,975 hospitalizations. CTCL was more likely to affect males and white patients. In multivariable logistic regression models controlling for age, sex, race, and insurance type, CTCL was associated with having any dermatological condition (adjusted odds ratio [aOR] 3.73, 95% CI: 3.557 - 2.353). Specifically, CTCL was associated with 16 of the 23 dermatological conditions, with pigmented purpuric dermatosis (aOR: 34.78, 95% CI: 14.44 - 83.76), lichen simplex chronicus (aOR: 14.323, 95% CI: 9.67 - 21.22), and dissecting cellulitis (aOR: 9.035, 95% CI: 5.44 - 15.00) having the greatest association with CTCL. Research regarding CTCL and associated dermatological conditions has been previously limited. Our study supports further investigation into CTCL associated comorbidities, due to its intricate pathogenesis.