Pos0946 association between parental autoimmune disease and atopic dermatitis in their offspring varied by sex: a nationwide case–control study

Background Association of parental autoimmune diseases and offspring atopy is unknown. Objectives Our study explored the association between paternal and maternal autoimmune diseases and occurrence of atopic dermatitis in their children in Taiwan. Methods The birth data between 2006 and 2012 from National Birth Registry was linked with National Health Insurance Research Database (2003-2017) in this study. We enrolled 312,329 mother-parent linkages when the children were diagnosed with atopic dermatitis before 5 years old, and compared them with 862,612 control parent-child linkages. Conditional logistic regression was utilized to calculate adjusted odds ratio (aOR) and 95% confidence interval (CI) when investigating the association between parental diseases and AD in their offspring. Results After adjusting for infant’s characteristics, perinatal factors, and other parental illnesses, the odds ratio of developing AD was 2.269 (95% CI 1.333-3.861) with parental rheumatoid arthritis and 1.610 (95% CI,1.094-2.369) with parental psoriasis. Parental allergic diseases such as AD (aOR 2.071, 95% CI 1.952-2.198) and asthma (aOR 1.494, 95% CI 1.400-1.594) were also significant predictors for childhood AD before 5 years old. Thus, parental autoimmune diseases could be one of the risk factors for subsequent AD development in their offspring. The subgroup analysis presented the different odds ratios of parental autoimmune diseases between children’s sex. Parental rheumatoid arthritis showed aOR of 3.070(95% CI, 1.532-6.154) in boys with AD, while parental psoriasis showed1.945(95% CI, 1.129-3.350) in girls with AD. Conclusion Parental autoimmune diseases were found to induce subsequent atopic dermatitis in their children before 5 years old, and there were different risk factors for atopic dermatitis between boys and girls. Table 1. Adjusted odds ratios of risk factors for childhood atopic dermatitis by using multivariate logistical regression analysis The parental diseases existed in Parental diseases Neither maternal nor paternal Only maternal Only paternal Both maternal and paternal Obstetric complications Preeclampsia Reference 1.001(0.977-1.027) GDM Reference 1.164(1.146-1.181 ) Cervical incompetence Reference 1.168(1.058-1.290 ) Autoimmune disease RA Reference 1.212(1.131-1.300 ) 1.153(1.062-1.252 ) 2.269(1.333-3.861 ) SLE Reference 1.177(1.093-1.267 ) Nil α Nil SS Reference 1.181(1.130-1.234 ) 1.127(1.053-1.206 ) 1.140(0.949-1.369 ) AS Reference 1.300(1.189-1.420 ) 1.187(1.130-1.247 ) 1.152(0.629-2.111) Psoriasis Reference 1.243(1.164-1.327 ) 1.118(1.055-1.186 ) 1.610(1.094-2.369 ) Systematic diseases Anemia Reference 1.030(1.018-1.043) 1.042(1.010-1.074) 1.090(1.051-1.130) HTN Reference 1.066(1.030-1.102) 1.115(1.092-1.139) 1.259(1.128-1.404 ) DM Reference 1.105(1.079-1.131) 1.116(1.081-1.152) 1.358(1.216-1.518 ) COPD Reference 1.186(1.150-1.224) 1.170(1.138-1.201) 1.213(1.110-1.325 ) Hyperthyroidism Reference 1.187(1.158-1.217) 1.148(1.091-1.207) 1.164(0.932-1.454) OSA Reference 1.265(1.145-1.398) 1.208(1.154-1.264) 0.700(0.417-1.178) Allergic disease Asthma Reference 1.286(1.258-1.315 ) 1.211(1.182-1.241 ) 1.494(1.400-1.594 ) AD Reference 1.474(1.454-1.495 ) 1.328(1.288-1.369 ) 2.071(1.952-2.198 ) NOTE: α Because the prevalence of SLE was largely higher in female, (female: male=14:1 in Taiwan, 2011) we only calculated the odds ratio of maternal SLE rather than taken the few male patients into consideration. The ORs of Obstetric complications was compared between maternal exposure and non-exposure. REFERENCES: NIL. Acknowledgements: NIL. Disclosure of Interests None Declared.