Trends In Age At Diagnosis, Incidence Proportion Of Benign Cardiac Neoplasms And Associated Outcomes: 2012-2021

Introduction: Incidence of benign cardiac neoplasms (BCNs) and outcomes in large scale studies among adults in US are unknown. We study this using TriNetX database. Methods: We queried TriNetX US Collaborative network housing data from insurance claims and electronic health records. We include adult patients with any ICD code from 01/01/12 - 12/31/21. ICD codes were used to identify BCN and ventricular arrhythmias, ischemic stroke and acute MI after BCN diagnosis. Mortality was identified by patients categorized as deceased after BCN diagnosis. Results: We identified 65.6 million patients (54% female), BCN prevalence was 0.0097% (n=6420). Mean (SD) age at diagnosis for males, females was 58.7 (18.2), 61.1 (17.5) years, respectively. Mean (SD) age at diagnosis increased from 57.2 (20.1) to 62.8 (16.9) years (P < 0.05). Incidence proportion for BCN in females and males was 0.013% and 0.010% respectively, no trend was seen in annual incidence proportion for either sex (P > 0.05). On comparing those with vs without BCN, BCN cases were at higher risk of mortality, Ventricular arrhythmia, Ischemic stroke, and acute MI with RR (95% CI); 3.56 (3.36-3.77), 11.9 (10.9-12.9), 10.09 (9.58-10.62) and 9.41 (8.84-10.02), respectively. The risk of mortality, ventricular arrhythmia, Acute MI and ischemic stroke in males vs females with BCN was 17.4% vs 15.3%, 4.6% vs 4.1%, 7.6% vs 9.2% and 7.5% vs 6.3%, respectively. Conclusion: Annual incidence proportion of BCNs remains stable from 2012-21. An increasing trend in age at BCN diagnosis is seen. Females have higher Incidence proportion and age at diagnosis. BCN patients are at risk of adverse outcomes with males having worse outcomes.