Decreased levels of g protein-coupled estrogen receptor in bipolar patients

Objectives: There is increasing evidence in the literature that estrogen and its receptors play an important role in the etiopathogenesis of bipolar disorder due to gender differences in the course, severity and peak periods of the disease. In this context, GPER, which is defined in the reproductive system as well as the nervous system, endocrine system and cardiovascular system, and mediates the neurological benefits of estradiol; It is important to better understand its role in this disease. Method: In this study, we aimed to compare serum GPER levels in euthymic bipolar disorder and healthy controls matched for age, sex and body mass index. Results: In this study, we found decreased serum GPER levels in both genders separately and in total in the patient groups compared to the control groups. Conclusion: Our results should be considered preliminary and should be repeated in more homogeneous groups with larger samples. In addition, we believe that further studies should be conducted on the therapeutic efficacy of G1 in depressive bipolar patients.