Genetically determined expression of lipoprotein lipase is linked to hepatocellular carcinoma in alcohol-associated cirrhosis

Franziska Schmalz,Janett Fischer,Hamish Innes,Jochen Hampe, Christina Möller,Madlen Matz‐Soja,Witigo von Schönfels,Benjamin M. Kraemer,Bettina Langhans,Alexandra Klüners,Michael Soyka,Felix Stickel,Jacob Nattermann,Christian Strassburg,Thomas Berg,Hans Dieter Nischalke,Philipp Lutz

Zeitschrift Fur Gastroenterologie（2023）

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摘要

Background Progression of alcohol-associated liver disease (ALD) is driven by genetic predisposition. The rs13702 variant in the lipoproteinlipase (LPL) gene is linked to non-alcoholic fatty liver disease, but LPL is not expressed in healthy liver. We aimed at clarifying its role in ALD.

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关键词

hepatocellular carcinoma,lipoprotein lipase,cirrhosis,alcohol-associated

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