Association between Serum Uric Acid and Obesity Indices in a Male T2DM population

Abstract Background Hyperuricemia (HUA), a growing global health issue, is a constant complication of type 2 diabetic mellitus (T2DM) in male patients. Previous research has shown that obesity and the development of hyperuricemia are closely related. The purpose of this study is to assess how these new lipid and obesity-related indices and UA levels in male T2DM patients relate to one another. Methods A cross-sectional study was carried out among 1160 male patients with T2DM in Jinan Central Hospital, Shandong University, China. Multivariate logistic analysis was performed to examine the relationship between the lipid and obesity-related indices and hyperuricemia after dividing these indices into four quartiles. Area under the curve (AUC) and receiver operating characteristic (ROC) curves were used to assess the ability of the indices to predict hyperuricemia values. Results Except for body mass index (BMI), other indices including atherogenic index of plasma (AIP), a body shape index (ABSI), body roundness index (BRI), cardiometabolic index (CMI), homeostatic model assessment for insulin resistance (HOMA-IR) index, lipid accumulation product (LAP) index, triglyceride glucose (TyG) index, waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) exhibited stronger associations with hyperuricemia. According to the maximum Youden index of 0.32, the LAP index had the highest AUC value of 0.71 (95% CI, 0.67–0.74, P = 0.00), with a cut-off value of 39.37 and sensitivity and specificity values of 80.00% and 52.00%, respectively. Conclusion The LAP index may be used as a possible monitoring indicator for hyperuricemia management in male T2DM patients since it is more significantly related with hyperuricemia than other anthropometric indices. Level II, controlled trial without randomization.