Metal–organic frameworks modified electrode for H₂S detections in biological and pharmaceutical agents

Abstract The development of hydrogen sulfide (H 2 S) sensors is essential to address H 2 S‐related pharmacology since slow‐releasing H 2 S medications have been identified to be prospective options for cancer treatments. Here, we described an electrochemical sensor for highly selective and sensitive detection of aqueous H 2 S, using a thin film of fumarate‐based face‐centered cubic ( fcu )‐based metal–organic frameworks (fum‐ fcu ‐MOF) modified on laser‐scribed graphene (LSGE). The fum‐ fcu ‐MOF has shown a strong affinity and chemical stability to H 2 S analysis. The electrochemical and H 2 S catalytic properties were studied for fum‐ fcu ‐MOF/LSGE. An amperometry and differential pulse voltammetry techniques were demonstrated to validate the sensor. The resulting sensor delivered acceptable analytical parameters in terms of; detection limit (3.0 µM), dynamic range (10–500 µM), reproducibility, and stability (94.7%). The sensor's practical validity was demonstrated in bacterial cells and H 2 S‐releasing drug, where the sensor was able to monitor the continuous release of in‐situ H 2 S. The pharmacokinetics of a slow releasing H 2 S donor is accessed at different time intervals and different concentration levels. Our research indicate that this fum‐ fcu ‐MOF based H 2 S sensor holds potential in understanding pharmacokinetics of H 2 S releasing drugs.