Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway

Corrigendum28 June 2023free access Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway Maria D Koffa Maria D Koffa Search for more papers by this author J Barklie Clements J Barklie Clements Search for more papers by this author Elisa Izaurralde Elisa Izaurralde orcid.org/0000-0001-7365-2649 Search for more papers by this author Sarah Wadd Sarah Wadd Search for more papers by this author Stuart A Wilson Stuart A Wilson Search for more papers by this author Iain W Mattaj Iain W Mattaj Search for more papers by this author Scott Kuersten Scott Kuersten Search for more papers by this author Maria D Koffa Maria D Koffa Search for more papers by this author J Barklie Clements J Barklie Clements Search for more papers by this author Elisa Izaurralde Elisa Izaurralde orcid.org/0000-0001-7365-2649 Search for more papers by this author Sarah Wadd Sarah Wadd Search for more papers by this author Stuart A Wilson Stuart A Wilson Search for more papers by this author Iain W Mattaj Iain W Mattaj Search for more papers by this author Scott Kuersten Scott Kuersten Search for more papers by this author Author Information Maria D Koffa, J Barklie Clements, Elisa Izaurralde, Sarah Wadd, Stuart A Wilson, Iain W Mattaj and Scott Kuersten The EMBO Journal (2023)42:e114021https://doi.org/10.15252/embj.2023114021 This article corrects the following: Herpes simplex virus ICP27 protein provides viral mRNAs with access to the cellular mRNA export pathway15 October 2001 PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info Figure 6A, corresponding legend and associated text statements are retracted. Journal statement Editors were made aware of an investigation by the University of Glasgow on this manuscript. The University investigation concluded that the data concerning Fig 6A were not authentic. The journal conducted its own data integrity analysis and concluded that image aberrations were apparent in Fig 6A. In the absence of source data, the editors, in agreement with the above-listed authors, and the University of Glasgow investigation panel, herewith retract Fig 6A, its corresponding legend and the associated text statements in the “results” section of the paper: The following text in the “results” section of the manuscript is retracted: "To investigate whether export of ICP27 protein under these conditions requires the same factors as ICP27-mediated viral RNA export, the inhibitors used above for the RNA export were tested on RNA-induced ICP27 export. A mix of [35S]methionine-labelled ICP27, GST–M10 and Rev proteins was co-injected into oocyte nuclei in the presence or the absence of Us11 RNA (Figure 6A). The Rev protein contains a leucine-rich NES and was used as a control for CRM1-mediated export. Under conditions where Rev export was drastically reduced either by co-injection of BSA–NES conjugates (Figure 6A, lanes 13 and 14) or by incubation in the presence of LMB (Figure 6A, lanes 15 and 16), there was no inhibition of RNA-mediated ICP27 protein accumulation in the cytoplasm. However, co-injection of excess CTE, which blocks viral mRNA export (Figure 5B), inhibited ICP27 protein accumulation in the cytoplasm (Figure 6A, lanes 9 and 10). These results suggest that ICP27 moves to the cytoplasm as a complex with the viral mRNA." Author statement The corrigendum has no effect on the conclusions of the manuscript as it refers to how ICP27 protein gets to the cytoplasm. The conclusions of the paper focus on the effect of ICP27 on transport of viral RNAs and this observation, although interesting, is not relevant to these conclusions. All authors agree with this statement. J. Barklie Clements and Elisa Izaurralde are deceased. Next ArticlePrevious Article Read MoreAbout the coverClose modalView large imageVolume 42,Issue 14,17 July 2023This cover highlights the article Deterministic and probabilistic fate decisions co‐exist in a single retinal lineage by Elisa Nerli, Caren Norden and colleagues. A combination of live imaging and stochastic modelling of single lineage decisions in the zebrafish retina reveals how different neuronal types arise in the correct proportions during development. The cover shows the retina at three days post‐fertilisation, when most neurons are formed and occupy different layers. The different layers are outlined with phalloidin staining in magenta, Muller glial cells are labelled in yellow and retinal ganglion cells in cyan. (Scientific image by the authors) Volume 42Issue 1417 July 2023In this issue RelatedDetailsLoading ...