Long‐term outcomes of modern multidisciplinary management of sinonasal cancers: The M. D. Anderson experience

Abstract Purpose To report long‐term outcomes of modern radiotherapy for sinonasal cancers. Methods and materials A retrospective analysis of patients with sinonasal tumors treated with intensity‐modulated radiotherapy or proton therapy. Multivariate analysis was used to determine predictive variables of progression free survival (PFS) and overall survival (OS). Results Three hundred and eleven patients were included, with median follow‐up of 75 months. The most common histologies were squamous cell (42%), adenoid cystic (15%), and sinonasal undifferentiated carcinoma (15%). Induction chemotherapy was administered to 47% of patients; 68% had adjuvant radiotherapy. Ten‐year local control, regional control, distant metastasis free survival, PFS, and overall survival rates were 73%, 88%, 47%, 32%, and 51%, respectively. Age, non‐nasal cavity tumor site, T3‐4 stage, neck dissection, and radiation dose were predictive of PFS, while age, non‐nasal cavity tumor site, T3‐4 stage, positive margins, neck dissection, and use of neoadjuvant chemotherapy were predictive of OS. There was a 13% rate of late grade ≥3 toxicities. Conclusion This cohort of patients with sinonasal cancer treated with modern radiotherapy demonstrates favorable disease control rate and acceptable toxicity profile.