Scalable production of mesoporous titanium nanoparticles through sequential flash nanocomplexation

Mesoporous titanium nanoparticles (MTNs) have emerged as an important porous semiconductor owning to their large surface area and unique electronic/optical properties. However, the fundamental research for rational manufacturing MTNs in a highly scalable manner remains a challenge. In this study, we report a two-step flash nanocomplexation (FNC) approach to large -scalable generate MTNs through the sequential combination of two multi -inlet vortex mixers. By optimizing the concentrated titanium precursor, polyethylene glycol (PEG)-functionalized silane amount and pH, we have been able to produce MTNs with small particle size (31.5 nm), larger surface area (416.9 m2/g) and pore volume (0.59 cm3/g). Different from the traditional MTNs bulk, FNC-produced MTNs exhibited well -controlled manner and exceptional photo catalytic and antibacterial properties. Importantly, the optimized MTNs outperformed commercial P25 not only in protecting ultraviolet A (UVA)-exposed skin, but also in treating P. aeruginosa-infected wound. We believe that the high controllability and scalability of sequential flash nanocomplexation method offers great opportunities in enhancing the performance of mesoporous titanium nanoparticles. (c) 2024 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.