Impact of mutational status on preoperative olfactory function in olfactory groove meningioma: Insights from a Clinical Study

Research Square (Research Square)(2023)

引用 0|浏览6
暂无评分
摘要
Abstract PURPOSE: The study aimed to analyze the impact of driver mutations and image characteristics of olfactory groove meningioma (OGM) on olfactory function. METHODS: Olfactory function was assessed in 22 patients with OGM using odor threshold, odor discrimination, odor identification, and a global olfactory score. Targeted sequencing was performed to define the most frequent OGM driver mutations in 52 patients. Image morphology was obtained from preoperative imaging. RESULTS: The cohort of 52 patients exhibited SMO/SUFU mutations in 17 (33%), AKT1 mutations in 13 (25%), and "other" mutations in 15 (29%) patients, while the remaining 7 (13%) tumors were wild-type. Tumor-associated planum hyperostosis was displayed in 75% of OGM, with the lowest frequency in the AKT1-mutated group (42%), the highest in the SMO/SUFU (82%) and WT-groups (100%); (p = .017). Related to OGM volume, there was a difference between AKT1 and wild-type mutated OGM cohort ([Median (Range) cm3]: [13 (3-45) cm3] vs. [44 (19-84) cm3]) (p = .008). The preoperative odor threshold correlated with the perifocal edema (p = .03). Odor identification was associated with tumor volume (p = .014) and hyperostosis of the planum (p = .005). CONCLUSIONS: The study provides a reference on the dependencies between imaging, clinical, and OGM mutational characteristics and preoperative olfactory performance. For the first time, it has been shown that PIK3CA, TRAF7-, POLR2A-, and NF1 OGM-mutation status is a tumor-related molecular predictor of the preoperative global olfactory performance. The preoperative olfactory status could contribute to more accurate surgical planning and postoperative patient support.
更多
查看译文
关键词
olfactory groove meningioma,preoperative olfactory function
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要