Comparison of Vitamin D plasma level in women with or without endometriosis: a case-control study

Abstract Background: Endometriosis is a debilitating gynecologic disease affecting millions of women worldwide. The potential role of vitamin D is of increasing interest. Previous studies have provoked controversy over the role of vitamin D and have shown a correlation between endometriosis and low vitamin D serum levels. This study aimed to assess and compare vitamin D serum levels between women with and without endometriosis. Materials & Methods: We studied 47 patients with endometriosis who visited the Infertility and Reproductive Clinic at our tertiary hospital and compared their vitamin D levels with healthy control subjects (47 women). The analysis was performed using Mann-Whitney and chi-square tests. Results: The median age of the women was 32/49, and SD was 5.42. The Mann-Whitney test showed no significant relationship between the mean levels of vitamin D and endometriosis diagnosis ( P = 0.223). However, most of the patients with low level of vitamin D have endometriosis. This was confirmed by the chi-square test (odds ratio [OR] = 3.410; P = 0.008). Conclusion: In conclusion, these results indicate that women with a low level of vitamin D are statistically at higher risk of endometriosis and maybe there is a relationship between vitamin D and endometriosis so more studies are needed to determine the role of vitamin d in endometriosis