Extraneural perineurioma of the mandible - a case report

A 36-year-old female patient was referred to a private clinic presenting an asymptomatic, intraosseous lesion in the posterior right mandible. Itraoral examination revealed no significant alteration. X-rays and cone-beam computed tomography exams revealed a well-defined, radiolucent, hypodense lesion with a sclerotic border in the right side of the mandible. The tumor appeared to cause fusiform enlargement of the mandibular canal. After an incisional biopsy, histopathological analysis revealed a proliferation of slender, spindle-shaped cells with long cell processes arranged in storiform and short-fascicular patterns. The findings were suggestive of extraneural perineurioma. Immunohistochemical reactions for S100, EMA, and Glut-1 antigens confirmed the diagnosis. The tumor was resected under general anesthesia. Follow-up is still ongoing. Funding: CAPES/Brazil; FAPEMIG/Brazil; CNPq/Brazil. A 36-year-old female patient was referred to a private clinic presenting an asymptomatic, intraosseous lesion in the posterior right mandible. Itraoral examination revealed no significant alteration. X-rays and cone-beam computed tomography exams revealed a well-defined, radiolucent, hypodense lesion with a sclerotic border in the right side of the mandible. The tumor appeared to cause fusiform enlargement of the mandibular canal. After an incisional biopsy, histopathological analysis revealed a proliferation of slender, spindle-shaped cells with long cell processes arranged in storiform and short-fascicular patterns. The findings were suggestive of extraneural perineurioma. Immunohistochemical reactions for S100, EMA, and Glut-1 antigens confirmed the diagnosis. The tumor was resected under general anesthesia. Follow-up is still ongoing. Funding: CAPES/Brazil; FAPEMIG/Brazil; CNPq/Brazil.