The Effect of Etoricoxib in Knee Osteoarthritis and its Impact on Immune Inflammatory Response

We aim to investigate the value of family rehabilitation training with etoricoxib treatment in knee osteoarthritis and its impact on immune inflammatory response. We selected 100 knee osteoarthritis patients admitted to our hospital from October 2021 to October 2022 and divided them into an experimental group (50 cases) and a control group (50 cases) according to the envelope randomization method. Control group received etoricoxib treatment and experimental group received family rehabilitation training with etoricoxib treatment. Compared the therapeutic effect of both groups, as well as the Western Ontario and McMaster universities osteoarthritis index scale score, Lysholm score, arthritis impact measurement scale score and immunoinflammatory response before and after 3 mo of treatment. The effective aggregate rate of 94.00 % in experimental group after family rehabilitation training with etoricoxib treatment was higher than the effective aggregate rate of 80.00 % in control group after etoricoxib treatment (p<0.05). After 3 mo of treatment, all Western Ontario and McMaster universities osteoarthritis index scale scores and arthritis impact measurement scale scores decreased in both groups and experimental group had lower Western Ontario and McMaster universities osteoarthritis index scale scores and arthritis impact measurement scale scores of joint function, stiffness and pain than control group; Lysholm scores increased in both groups, and experimental group had higher Lysholm scores than control group (p<0.05). After 3 mo of treatment, all immune inflammatory response indicators decreased in both groups, and experimental group had lower interleukin-1, nuclear factor-kappa B and matrix metalloproteinase 3 indicators than control group (p<0.05). In the treatment of knee osteoarthritis disease, family rehabilitation training with etoricoxib has a significant effect, which helps to reduce the level of immune inflammatory response and promote the recovery of their knee joint function.