Abstract 10042: Mental Health Conditions In Congenital Heart Disease: A Danish Population Based Cohort Study

Introduction: We aimed to investigate mental health condition development by 18 years of age among children with congenital heart disease (CHD). Methods: Using Danish health registry data, all children with CHD (n=17,153) were identified from 1996-2017. Mental health conditions were identified using hospital-based diagnoses, medication prescription, and treatment codes during the study period (1996-2019). Children with mental health conditions diagnosed prior to CHD were excluded (n=670, 3.9%). Comparison cohorts included the general population (matched 10:1 for age and sex), siblings of children with CHD, and children with non-CHD major congenital anomalies (MCAs) identified via EUROCAT codes and matched 3:1 for age and sex. Incidence rates per 1,000 person-years, cumulative incidence per 100 persons, and adjusted hazard ratios (aHR [95% CI]) were calculated and stratified by age-based follow-up periods, CHD severity, and sex. Results: The CHD cohort had higher overall rates of mental health conditions than their siblings (aHR 1.41 [1.30-1.52]) and the general population (aHR 1.66 [1.60-1.72]), and when stratified by age periods, CHD severity, and sex (Table 1). The cumulative incidence in the CHD cohort was 35.7% compared with 25.6%, 26.6%, and 35.1% for the general population, sibling, and MCA cohorts, respectively (Figure 1). Conclusions: This population-based cohort study shows that children with CHD are more likely to be diagnosed with mental health conditions by age 18 years than their siblings and the general population, but not children with non-CHD MCAs. Investigation to determine relevant clinical, sociodemographic, and family risk factors is ongoing.