MicropeptideMIAC Inhibits HNSCC Progression by Interactingwith Aquaporin 2
Figshare documentation (Figshare (United Kingdom))(2020)
摘要
Several
important micropeptides encoded by noncoding RNAs have
been identified in recent years; however, there have never been any
reports of micropeptides in head and neck squamous cell carcinoma
(HNSCC). Here we report the discovery and characterization of a human
endogenous peptide named micropeptide inhibiting actin cytoskeleton
(MIAC). Comprehensive analysis of the TCGA (The Cancer Genome Atlas)
database (n = 500), clinical fresh samples (n = 94), and tissue microarrays (n = 60)
revealed that lower MIAC expression is correlated with poor overall
survival of HNSCC patients. Meanwhile, RNA-sequencing analysis of
9657 human tissues across 32 cancer types from TCGA cohorts found
that MIAC is significantly associated with the progression of 5 other
different tumors. Mechanistically, MIAC directly interacts with AQP2
(Aquaporin 2) to inhibit the actin cytoskeleton by regulating SEPT2
(Septin 2)/ITGB4 (Integrin Beta 4) and ultimately suppressing the
tumor growth and metastasis of HNSCC. Collectively, the mechanism
investigation and evaluation of MIAC activity in vivo and in vitro highlights that MIAC plays an important
role in HNSCC tumorigenesis.
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关键词
interactingwith aquaporin
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