Effect of Telmisartan on Glycometabolism and Serum Adiponectin in Spontaneously Hypertensive Rats

【Objective】 The aim of the study was to evaluated the effect of telmisartan, an Angiotensin II type 1 receptor antagonist, on glycometabolism and serum adiponectin in spontaneously hypertensive rats(SHR). 【Methods】 Rats were randomly assigned to four groups: control groups(WKY, n = 10); spontaneously hypertensive groups(SHR, n = 10); telmisartan groups(telmisartan, 50 mg /(kg·d), n = 10), amlodipine groups(amlodipine, 10 mg /(kg· d), n = 10), the other two groups were given placebo, the all rats were gavaged for 12 weeks. Glycometabolism were measured by biochemistry methods. Serum insulin levels were measured using radio-immunity methods. Changes of serum adiponectin were measured by ELISA. 【Result】 No significant difference of fasting blood glucose was observed in four groups(P 0.05). Serum insulin level in SHR was higher than that of WKY groups(P 0.05), Telmisartan and amlodipine could not reduce fasting insulin level in SHR. The result of OGTT showed that blood glucose level in SHR at 30 min or 120 min was higher than WKY groups, and telmisartan could significantly reduce blood glucose level in SHR(P 0.05), but amlodipine was not effective(P 0.05). Serum adiponectin level in SHR was lower than that of WKY, and telmisartan could obviously increase that in SHR(P 0.05), but amlodopine could not increase that. 【Conclusion】 Telmisartan could ameliorate the downregulation of serum adiponectin level in SHR, and reduce blood glucose level of OGTT at 30 and 120 min in SHR.