Ultrasound-Promoted Nanoreagent for Homologous Targeted Synergistic Chemodynamic/Sonodynamic Tumor Therapy

The establishment of a tumor theranostic platform with high efficacy is attracting considerable interest in cancer treatment. Nevertheless, considerable obstacles need to be overcome in developing such a platform. In this study, a versatile theranostic system (CM-FMNPs-Cur) was produced utilizing MnO2 nanoflowers, which provided targeted and synergistic therapy for cancer through the incorporation of sonodynamic and chemodynamic therapies. By integrating Fe3O4, MnO2, and curcumin, CM-FMNPs-Cur manifests a substantial amount of reactive oxygen species toward deep-seated cancers. As a sonosensitizer, curcumin was used for chemodynamic therapy (CDT)_and sonodynamic therapy (SDT). In the acidic environment of malignant cells, CM-FMNPs-Cur can decompose into Mn2+ and Fe2+, triggering a Fenton-like reaction and generating 'OH radicals and oxygen. Ameliorating tumor hypoxia also enhanced the effectiveness of SDT in neoplasms. IP: 2038 109 10 On: Fri 15 Sep 2023 2237 07 The homologous targeting effect of CM-FMNPs-Cur on cancer cell membranes led to its accumulation in the tumor region. Copyright: American Scentific Publishers Here, the mutual promotion of CDT and SDT resultd in an amplified therapeutic outcome. All these results revealed the Del vered by Ingenta vast potential of CM-FMNPs-Cur for secure and highly effective collaborative tumor treatment, indicating future clinical applications.