From heart to gut: Exploring the gut microbiome in congenital heart disease

Congenital heart disease (CHD) is a prevalent birth defect and a significant contributor to childhood mortality. The major characteristics of CHD include cardiovascular malformations and hemodynamical disorders. However, the impact of CHD extends beyond the circulatory system. Evidence has identified dysbiosis of the gut microbiome in patients with CHD. Chronic hypoxia and inflammation associated with CHD affect the gut microbiome, leading to alterations in its number, abundance, and composition. The gut microbiome, aside from providing essential nutrients, engages in direct interactions with the host immune system and indirect interactions via metabolites. The abnormal gut microbiome or its products can translocate into the bloodstream through an impaired gut barrier, leading to an inflammatory state. Metabolites of the gut microbiome, such as short-chain fatty acids and trimethylamine N-oxide, also play important roles in the development, treatment, and prognosis of CHD. This review discusses the role of the gut microbiome in immunity, gut barrier, neurodevelopment, and perioperative period in CHD. By fostering a better understanding of the cross-talk between CHD and the gut microbiome, this review aims to contribute to improve clinical management and outcomes for CHD patients. Children with congenital heart disease (CHD) experience gut microbiome dysbiosis in their early life. The gut microbiome affects CHD via immune stimulation and microbiome metabolites, influencing immunity, gut barrier, and inflammation. The bidirectional interaction between the gut microbiome and CHD plays an important role in CHD's development, treatment, and prognosis.Highlightsimage Children with CHD experience gut microbiome dysbiosis in their early life.The gut microbiome affects CHD via immune stimulation and microbiome metabolites, influencing immunity, gut barrier, and inflammation.The bidirectional interaction between the gut microbiome and CHD plays an important role in CHD's development, treatment, and prognosis.