Systemic coagulation inflammation index associated with bleeding in acute coronary syndrome

Aim: Assessment of the inflammatory component of acute coronary syndrome (ACS) and the degree of activation of the coagulation cascade may provide prognostic information. The systemic coagulation-inflammation index (SCI) assesses both inflammation and the coagulation system, and it has also been found to be associated with clinical outcomes. We investigated the relationship between SCI and in-hospital clinical events (acute kidney injury, cardiogenic shock, life-threatening arrhythmia, bleeding) and mortality.Material and methods: The study included 396 patients aged >= 18 yrs who were hospitalized with a diagnosis of ACS. The SCI was calculated using the formula: platelet count (103 / mu l) X fibrinogen (g / l) / white blood cell (WBC) count (103 / mu l). Patients were divided into two groups according to whether their SCI score was > 100 or < 100, and the relationship between clinical and laboratory characteristics was analyzed accordingly.Results: The mean age of the patients was 61.4 +/- 12.2 years and 78.3 % (n=310) were male. The type of ACS was NSTEMI in 56.1 % (n=222). The responsible vessel was the left anterior descending artery (LAD) in 42.4 % of the patients (n=168). The mean SCI score was 97.5 +/- 47.1. WBC, neutrophil, and lymphocyte counts were higher in the SCI < 100 group, whereas fibrinogen, C-reactive protein, and platelet count were higher in the SCI > 100 group. Bleeding from any cause as an in-hospital complication was significantly higher in patients with SCI > 100 (p < 0.05). Other in-hospital events were not significantly associated with SCI (p > 0.05).Conclusions: Bleeding in ACS patients was significantly more common in the group with SCI > 100. Thus, SCI may be a useful parameter for predicting in-hospital bleeding complications in ACS. On the other hand, SCI was not associated with mortality and other in-hospital clinical events.