Hypervalent Iodine‐Mediated Alkyne Functionalization: Facile Access to Trifluoromethyl‐ and Pentafluoroethyl‐Substituted Thiazoles

The use of hypervalent iodine with Lewis acid provided alkyne trifluoromethylation and pentafluoroethylation to access trifluoro-and pentafluoro-substituted thiazoles. This simple and efficient method is compatible with a broad range of aryl- and alkyl-substituted thiourea starting materials. Additionally, a gram-scale reaction proves the practicality of this transformation. The use of hypervalent iodine with Lewis acid provided alkyne trifluoromethylation and pentafluoroethylation to access trifluoro-and pentafluoro-substituted thiazoles.image