Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing

Exudate management and bioelectric signals are critical to promoting wound healing. In this study, the thermoplastic polyurethane (TPU) nanofiber is directly electrospun on the cotton microfibers (Cotton) to prepare a Janus dressing (TPU/Cotton), which can unidirectionally drain the excess exudate. Then, Ag/Zn dot electrodes are deposited on the TPU layer, which can produce an electric field penetrating the wound when activated by wound exudate. The hydro-activated Ag/Zn's electrical stimulation (ES) can promote the migration of fibroblast cells and shows excellent antibacterial activity against E. coli and S. aureus. Furthermore, in vivo experiments show that the exudate management coupled with ES accelerated wound healing at multiple stages by promoting re-epithelization, collagen deposition, and vascularization. Moreover, the Ag/Zn@TPU/Cotton dressing shows excellent biocompatibility in the vitro cytotoxicity experiments. These findings may shed some light on developing the next generation of wound dressings with self-activated electrical stimulation and exudate management. Ag/Zn dots are deposited on the thermoplastic polyurethane (TPU) layer of TPU/cotton nonwovens (Cotton). The hydro-activated Ag/Zn's electrical stimulation (ES) can promote the migration of fibroblast cells and show excellent antibacterial activity against E. coli and S. aureus. The exudate management coupled with ES can accelerate wound healing at multiple stages by promoting re-epithelization, collagen deposition, and vascularization.image