Disrupted Circadian Rhythms and Mental Health

The link between circadian rhythms and mental health is extensive. Circadian rhythm disruptions are commonly observed across many different psychiatric disorders and perturbation of the circadian system can precipitate or exacerbate psychiatric episodes. Together, this demonstrates a significant reciprocal relationship between circadian rhythm and mental health. Despite the extensive evidence linking circadian rhythms and mental health, studies are only beginning to uncover the neurobiological basis of this relationship. This chapter will provide an overview of the link between the circadian system and mental health. With the idea of a reciprocal relationship in mind, we will first discuss examples of circadian rhythm disruptions that impact mental health, such has exposure to artificial lighting, jetlag, and seasonal affective disorder. We will then discuss examples of psychiatric disorders and the circadian contribution to the pathophysiology of these disorders. Lastly, we will discuss strategies aimed at treating psychiatric disorders by targeting the circadian system.