Making sense of multiorgan MRI imaging for post-acute sequelae of SARS-CoV-2 infection.

The most common physical symptoms of post-acute sequelae of SARS-CoV-2 infection (also known as long COVID) are fatigue and shortness of breath, and the most common mental symptoms are cognitive impairment, sleep difficulties, and mood disorders including depression and anxiety. 1 Huang C Huang L Wang Y et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2023; 401: e21-e33 Summary Full Text Full Text PDF Google Scholar Although clinical, radiographic, and autopsy studies of patients with acute COVID-19 have identified dysregulated immunity, endothelial dysfunction, and microthrombosis as SARS-CoV-2-specific mechanisms of multiorgan injury, 2 Parotto M Gyöngyösi M Howe K et al. Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations. Lancet Respir Med. 2023; 11: 739-754 Summary Full Text Full Text PDF Google Scholar the potential permanent organ damage in those who have had COVID-19 and pathobiology that underlies the symptoms of long COVID remain poorly understood. Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort studyAfter hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification. Full-Text PDF Open Access